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bmp 4 groups  (MedChemExpress)


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    MedChemExpress bmp 4 groups
    Effects of CdCl 2 on BMP/SMAD pathway. The hBMSCs were exposed to 0, 2.5, or 5.0 μM CdCl 2 and subjected to osteogenic differentiation for 14 days. A and C, Western blots were performed, and (B and D) relative protein levels of BMP-2, <t>BMP-4,</t> BMP-6, BMP-7, SMAD1, p-SMAD1, SMAD4, SMAD5, and p-SMAD1/5/9 were determined. E and F, Expression levels of BMP-2 and BMP-4 were detected by ELISA. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). * p < .05, ** p < .01, different from hMSCs in the absence of CdCl 2 . Abbreviations: BMP, bone morphogenetic protein; hBMSC, human bone marrow mesenchymal stem cell.
    Bmp 4 Groups, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bmp 4 groups/product/MedChemExpress
    Average 94 stars, based on 7 article reviews
    bmp 4 groups - by Bioz Stars, 2026-02
    94/100 stars

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    1) Product Images from "Bone morphogenetic protein 4 is involved in cadmium-associated bone damage"

    Article Title: Bone morphogenetic protein 4 is involved in cadmium-associated bone damage

    Journal: Toxicological Sciences

    doi: 10.1093/toxsci/kfac121

    Effects of CdCl 2 on BMP/SMAD pathway. The hBMSCs were exposed to 0, 2.5, or 5.0 μM CdCl 2 and subjected to osteogenic differentiation for 14 days. A and C, Western blots were performed, and (B and D) relative protein levels of BMP-2, BMP-4, BMP-6, BMP-7, SMAD1, p-SMAD1, SMAD4, SMAD5, and p-SMAD1/5/9 were determined. E and F, Expression levels of BMP-2 and BMP-4 were detected by ELISA. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). * p < .05, ** p < .01, different from hMSCs in the absence of CdCl 2 . Abbreviations: BMP, bone morphogenetic protein; hBMSC, human bone marrow mesenchymal stem cell.
    Figure Legend Snippet: Effects of CdCl 2 on BMP/SMAD pathway. The hBMSCs were exposed to 0, 2.5, or 5.0 μM CdCl 2 and subjected to osteogenic differentiation for 14 days. A and C, Western blots were performed, and (B and D) relative protein levels of BMP-2, BMP-4, BMP-6, BMP-7, SMAD1, p-SMAD1, SMAD4, SMAD5, and p-SMAD1/5/9 were determined. E and F, Expression levels of BMP-2 and BMP-4 were detected by ELISA. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). * p < .05, ** p < .01, different from hMSCs in the absence of CdCl 2 . Abbreviations: BMP, bone morphogenetic protein; hBMSC, human bone marrow mesenchymal stem cell.

    Techniques Used: Western Blot, Expressing, Enzyme-linked Immunosorbent Assay

    Association among Cd, BMP-4, and osteoporosis. The mediating role of plasma BMP-4 ligand in the relationship between U-Cd and occurrence of osteoporosis. Causal mediation analysis estimated the indirect effect of U-Cd on osteoporosis through plasma BMP-4 ligand. Abbreviations: BMP, bone morphogenetic protein; CI, confidence interval; DE, direct effect; IE, indirect effect; PM, proportion mediated; U-Cd, urinary cadmium.
    Figure Legend Snippet: Association among Cd, BMP-4, and osteoporosis. The mediating role of plasma BMP-4 ligand in the relationship between U-Cd and occurrence of osteoporosis. Causal mediation analysis estimated the indirect effect of U-Cd on osteoporosis through plasma BMP-4 ligand. Abbreviations: BMP, bone morphogenetic protein; CI, confidence interval; DE, direct effect; IE, indirect effect; PM, proportion mediated; U-Cd, urinary cadmium.

    Techniques Used: Clinical Proteomics

    The osteogenic effect of BMP-4 on hBMSCs. The hBMSCs were treated with BMP-4 (50 ng/ml) and/or CdCl 2 (5.0 μM) for 14 days. A, The BMP-4 levels detected by ELISA. B, Mineralization was measured using Alizarin Red S staining. C, Western blots were performed. D, Relative protein levels of Runx2, OSX, SMAD4, and p-SMAD1/5/9 complex were determined. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). ∗ p < .05, ** p < .01. Abbreviations: BMP, bone morphogenetic protein; hBMSC, human bone marrow mesenchymal stem cell.
    Figure Legend Snippet: The osteogenic effect of BMP-4 on hBMSCs. The hBMSCs were treated with BMP-4 (50 ng/ml) and/or CdCl 2 (5.0 μM) for 14 days. A, The BMP-4 levels detected by ELISA. B, Mineralization was measured using Alizarin Red S staining. C, Western blots were performed. D, Relative protein levels of Runx2, OSX, SMAD4, and p-SMAD1/5/9 complex were determined. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). ∗ p < .05, ** p < .01. Abbreviations: BMP, bone morphogenetic protein; hBMSC, human bone marrow mesenchymal stem cell.

    Techniques Used: Enzyme-linked Immunosorbent Assay, Staining, Western Blot

    The effects of BMP-4 knockdown on osteogenic differentiation and SMADs. After si-BMP-4 transfect the hBMSCs were osteogenic induction for 14 days. A, Mineralization was measured using Alizarin Red S staining. B, Western blots were performed. C, Relative protein levels of BMP-4, Runx2, OSX, SMAD4, and p-SMAD1/5/9 complex were determined. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). ** p < .01.
    Figure Legend Snippet: The effects of BMP-4 knockdown on osteogenic differentiation and SMADs. After si-BMP-4 transfect the hBMSCs were osteogenic induction for 14 days. A, Mineralization was measured using Alizarin Red S staining. B, Western blots were performed. C, Relative protein levels of BMP-4, Runx2, OSX, SMAD4, and p-SMAD1/5/9 complex were determined. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). ** p < .01.

    Techniques Used: Knockdown, Staining, Western Blot



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    bmp 4 groups  (MedChemExpress)
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    MedChemExpress bmp 4 groups
    Effects of CdCl 2 on BMP/SMAD pathway. The hBMSCs were exposed to 0, 2.5, or 5.0 μM CdCl 2 and subjected to osteogenic differentiation for 14 days. A and C, Western blots were performed, and (B and D) relative protein levels of BMP-2, <t>BMP-4,</t> BMP-6, BMP-7, SMAD1, p-SMAD1, SMAD4, SMAD5, and p-SMAD1/5/9 were determined. E and F, Expression levels of BMP-2 and BMP-4 were detected by ELISA. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). * p < .05, ** p < .01, different from hMSCs in the absence of CdCl 2 . Abbreviations: BMP, bone morphogenetic protein; hBMSC, human bone marrow mesenchymal stem cell.
    Bmp 4 Groups, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bmp 4 groups/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    bmp 4 groups - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier

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    Effects of CdCl 2 on BMP/SMAD pathway. The hBMSCs were exposed to 0, 2.5, or 5.0 μM CdCl 2 and subjected to osteogenic differentiation for 14 days. A and C, Western blots were performed, and (B and D) relative protein levels of BMP-2, BMP-4, BMP-6, BMP-7, SMAD1, p-SMAD1, SMAD4, SMAD5, and p-SMAD1/5/9 were determined. E and F, Expression levels of BMP-2 and BMP-4 were detected by ELISA. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). * p < .05, ** p < .01, different from hMSCs in the absence of CdCl 2 . Abbreviations: BMP, bone morphogenetic protein; hBMSC, human bone marrow mesenchymal stem cell.

    Journal: Toxicological Sciences

    Article Title: Bone morphogenetic protein 4 is involved in cadmium-associated bone damage

    doi: 10.1093/toxsci/kfac121

    Figure Lengend Snippet: Effects of CdCl 2 on BMP/SMAD pathway. The hBMSCs were exposed to 0, 2.5, or 5.0 μM CdCl 2 and subjected to osteogenic differentiation for 14 days. A and C, Western blots were performed, and (B and D) relative protein levels of BMP-2, BMP-4, BMP-6, BMP-7, SMAD1, p-SMAD1, SMAD4, SMAD5, and p-SMAD1/5/9 were determined. E and F, Expression levels of BMP-2 and BMP-4 were detected by ELISA. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). * p < .05, ** p < .01, different from hMSCs in the absence of CdCl 2 . Abbreviations: BMP, bone morphogenetic protein; hBMSC, human bone marrow mesenchymal stem cell.

    Article Snippet: For BMP-4 groups, the medium included 50 ng/ml of recombinant BMP-4 (MedChemexpress).

    Techniques: Western Blot, Expressing, Enzyme-linked Immunosorbent Assay

    Association among Cd, BMP-4, and osteoporosis. The mediating role of plasma BMP-4 ligand in the relationship between U-Cd and occurrence of osteoporosis. Causal mediation analysis estimated the indirect effect of U-Cd on osteoporosis through plasma BMP-4 ligand. Abbreviations: BMP, bone morphogenetic protein; CI, confidence interval; DE, direct effect; IE, indirect effect; PM, proportion mediated; U-Cd, urinary cadmium.

    Journal: Toxicological Sciences

    Article Title: Bone morphogenetic protein 4 is involved in cadmium-associated bone damage

    doi: 10.1093/toxsci/kfac121

    Figure Lengend Snippet: Association among Cd, BMP-4, and osteoporosis. The mediating role of plasma BMP-4 ligand in the relationship between U-Cd and occurrence of osteoporosis. Causal mediation analysis estimated the indirect effect of U-Cd on osteoporosis through plasma BMP-4 ligand. Abbreviations: BMP, bone morphogenetic protein; CI, confidence interval; DE, direct effect; IE, indirect effect; PM, proportion mediated; U-Cd, urinary cadmium.

    Article Snippet: For BMP-4 groups, the medium included 50 ng/ml of recombinant BMP-4 (MedChemexpress).

    Techniques: Clinical Proteomics

    The osteogenic effect of BMP-4 on hBMSCs. The hBMSCs were treated with BMP-4 (50 ng/ml) and/or CdCl 2 (5.0 μM) for 14 days. A, The BMP-4 levels detected by ELISA. B, Mineralization was measured using Alizarin Red S staining. C, Western blots were performed. D, Relative protein levels of Runx2, OSX, SMAD4, and p-SMAD1/5/9 complex were determined. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). ∗ p < .05, ** p < .01. Abbreviations: BMP, bone morphogenetic protein; hBMSC, human bone marrow mesenchymal stem cell.

    Journal: Toxicological Sciences

    Article Title: Bone morphogenetic protein 4 is involved in cadmium-associated bone damage

    doi: 10.1093/toxsci/kfac121

    Figure Lengend Snippet: The osteogenic effect of BMP-4 on hBMSCs. The hBMSCs were treated with BMP-4 (50 ng/ml) and/or CdCl 2 (5.0 μM) for 14 days. A, The BMP-4 levels detected by ELISA. B, Mineralization was measured using Alizarin Red S staining. C, Western blots were performed. D, Relative protein levels of Runx2, OSX, SMAD4, and p-SMAD1/5/9 complex were determined. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). ∗ p < .05, ** p < .01. Abbreviations: BMP, bone morphogenetic protein; hBMSC, human bone marrow mesenchymal stem cell.

    Article Snippet: For BMP-4 groups, the medium included 50 ng/ml of recombinant BMP-4 (MedChemexpress).

    Techniques: Enzyme-linked Immunosorbent Assay, Staining, Western Blot

    The effects of BMP-4 knockdown on osteogenic differentiation and SMADs. After si-BMP-4 transfect the hBMSCs were osteogenic induction for 14 days. A, Mineralization was measured using Alizarin Red S staining. B, Western blots were performed. C, Relative protein levels of BMP-4, Runx2, OSX, SMAD4, and p-SMAD1/5/9 complex were determined. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). ** p < .01.

    Journal: Toxicological Sciences

    Article Title: Bone morphogenetic protein 4 is involved in cadmium-associated bone damage

    doi: 10.1093/toxsci/kfac121

    Figure Lengend Snippet: The effects of BMP-4 knockdown on osteogenic differentiation and SMADs. After si-BMP-4 transfect the hBMSCs were osteogenic induction for 14 days. A, Mineralization was measured using Alizarin Red S staining. B, Western blots were performed. C, Relative protein levels of BMP-4, Runx2, OSX, SMAD4, and p-SMAD1/5/9 complex were determined. These are the results from 3 independent biological replicates experiments (mean ± SD, n = 3). ** p < .01.

    Article Snippet: For BMP-4 groups, the medium included 50 ng/ml of recombinant BMP-4 (MedChemexpress).

    Techniques: Knockdown, Staining, Western Blot